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Human Monitoring for Genetic Effects
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SYSNO ASEP 0173760 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Early and late effects of 1,2-dibromoethane on the hematopoiesis of the chick embryo in ovo Author(s) Dušek, Zdík (UEM-P)
Novotná, Božena (UEM-P)
Holejšovská, Iva (UEM-P)
Dostál, Miroslav (UEM-P) RID
Vilhelmová, M. (CZ)Source Title Human Monitoring for Genetic Effects. - Amsterdam : IOS Press, 2003 / Cebulska-Wasilewska A. ; Au W. W. ; Šrám R. - ISSN 1566-7693 Pages s. 318-328 Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords chick embryo ; 1,2-dibromoethane ; haematopoiesis Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA304/98/1613 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5039906 - UEM-P Annotation Chick embryo in ovo was shown to be a promising system to study the effect of 1,2-dibromoethane (DBE) on haematopoiesis at a developmental stage where the primitive erythroid cells divide and differentiate in circulation. The kinetics of DNA breaks in both erythroid and lymphoid cells implied a genotoxic damage by DBE to the stem cells of the definitive elements and the transmission of this damage through the successive cell generations. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2004
Number of the records: 1