0173736 - UEM-P 20033057 RIV GB eng J - Journal Article
Krejčí, P. - Faitová, Jitka - Laurell, H. - Hampl, Aleš - Dvořák, Petr
FGF-2 expression and its action in human leukemia and lymphoma cell lines.
Leukemia. Roč. 17, - (2003), s. 818-820. ISSN 0887-6924. E-ISSN 1476-5551
R&D Projects: GA MŠMT LN00A065; GA MŠMT ME 198
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 432100001
Keywords : leukemia
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.116, year: 2003

It was shown that while the majority of human leukemia and lymphoma cell lines synthesizes low molecular mass FGF-2, its release is generally insufficient. However, several cell lines display prerequisites to respond to the extracellular FGF-2 that could be produced by other cell types. Importantly, in a majority of cell lines was found concomitant expression of two potent antiapoptotic molecules, high molecular mass FGF-2 and FGF-2-interacting protein FIF. This opens the possibility of their participation in the regulation of apoptosis.
Permanent Link: http://hdl.handle.net/11104/0070762