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Imaging the Fate of Implanted Bone Marrow Stromal Cells Labeled With Superparamagnetic Nanoparticles
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SYSNO ASEP 0173720 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Imaging the Fate of Implanted Bone Marrow Stromal Cells Labeled With Superparamagnetic Nanoparticles Author(s) Jendelová, Pavla (UEM-P) RID, ORCID
Herynek, V. (CZ)
DeCroos, Jane (UEM-P)
Růžičková, Kateřina (UEM-P)
Andersson, Benita (UEM-P)
Hájek, M. (CZ)
Syková, Eva (UEM-P) RIDSource Title Magnetic Resonance in Medicine. - : Wiley - ISSN 0740-3194
č. 50 (2003), s. 767-776Number of pages 10 s. Language eng - English Country US - United States Keywords cell transplantation ; magnetic resonance Subject RIV FH - Neurology R&D Projects IPP1050128 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LN00A065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA304/03/1189 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5039906 - UEM-P MSM 11130004 MZd:00023001 Annotation In animals with a cortical photochemical lesion, the fate of rat MSCs co-labeled with magnetic iron-oxide nanoparticles (Endorem) and bromodeoxyuridine (BrdU) was studied. MSCs were either grafted intracerebrally into the contralateral hemisphere of adult rat brain or injected intravenously. In vivo MR imaging was used to track their fate; prussian blue staining and transmission electron microscopy confirmed the presence of iron-oxide nanoparticles inside the cells. The implanted cells were visible on MR images as a hypointense area at the injection site and in the lesion. The presence of BrdU-positive and iron-containing cells was confirmed by subsequent histological staining. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2004
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