0173720 - UEM-P 20033039 RIV US eng J - Journal Article
Jendelová, Pavla - Herynek, V. - DeCroos, Jane - Růžičková, Kateřina - Andersson, Benita - Hájek, M. - Syková, Eva
Imaging the Fate of Implanted Bone Marrow Stromal Cells Labeled With Superparamagnetic Nanoparticles.
Magnetic Resonance in Medicine. č. 50 (2003), s. 767-776. ISSN 0740-3194. E-ISSN 1522-2594
R&D Projects: GA AV ČR IPP1050128; GA MŠMT LN00A065; GA ČR GA304/03/1189
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 11130004; CEZ:MZd:00023001
Keywords : cell transplantation * magnetic resonance
Subject RIV: FH - Neurology
Impact factor: 3.313, year: 2003

In animals with a cortical photochemical lesion, the fate of rat MSCs co-labeled with magnetic iron-oxide nanoparticles (Endorem) and bromodeoxyuridine (BrdU) was studied. MSCs were either grafted intracerebrally into the contralateral hemisphere of adult rat brain or injected intravenously. In vivo MR imaging was used to track their fate; prussian blue staining and transmission electron microscopy confirmed the presence of iron-oxide nanoparticles inside the cells. The implanted cells were visible on MR images as a hypointense area at the injection site and in the lesion. The presence of BrdU-positive and iron-containing cells was confirmed by subsequent histological staining.
Permanent Link: http://hdl.handle.net/11104/0070746