0173686 - UEM-P 20033002 RIV US eng J - Journal Article
Zídek, Zdeněk - Potměšil, Petr - Holý, Antonín
Cystatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.
Toxicology and Applied Pharmacology. Roč. 192, - (2003), s. 246-253. ISSN 0041-008X. E-ISSN 1096-0333
R&D Projects: GA ČR GA305/00/0048
Institutional research plan: CEZ:AV0Z4055905; CEZ:AV0Z5039906
Keywords : acyclic nucleoside phosphonates
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 2.851, year: 2003

The major mechanism of antiviral action of acyclic nucleoside phosphonates is inhibition of virus-induced DNA polymerases and of reverse transcriptases. They inhibit eukaryotic DNA polymerases, as well. Their suppressive effects on proliferation of mammalian lymphocytes differ greatly in dependence on the chemical structure. No tight correlation between the cytostatic and antiviral effects has been observed.
Permanent Link: http://hdl.handle.net/11104/0070713