0173636 - UEM-P 20023087 RIV US eng J - Journal Article
Kuchárová-Mahmood, S. - Raška, Ivan - Mechler, B. M. - Farkaš, R.
Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors.
Journal of Structural Biology. Roč. 140, - (2002), s. 67-78. ISSN 1047-8477. E-ISSN 1095-8657
R&D Projects: GA ČR GA304/02/0342
Grant - others:GA-(SK) VEGA:2/7194/20
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 111100003
Keywords : programmed cell death * BR-C transcription factors * drosophila
Subject RIV: EA - Cell Biology
Impact factor: 4.194, year: 2002

The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration.
Permanent Link: http://hdl.handle.net/11104/0070665