0173592 - UEM-P 20023037 RIV US eng J - Journal Article
Preclíková, H. - Bryja, Vítězslav - Pacherník, J. - Krejčí, P. - Dvořák, Petr - Hampl, Aleš
Early cycling-independent changes to p27, cyclin D2, and cyclin D3 in differentiating mouse embryonal carcinoma cells.
Cell Growth and Differentitation. Roč. 13, - (2002), s. 421-430. ISSN 1044-9523
R&D Projects: GA ČR GA204/01/0905
Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 432100001
Keywords : differentiation
Subject RIV: ED - Physiology
Impact factor: 3.642, year: 2002

This study investigates how the amount of the inhibitor of cyclin-dependent kinases p27 relates to the transition from nondifferentiated to differentiated status in pluripotent cells of embryonal origin. It demonstrates that the amounts of p27 and D-type cyclins themselves cannot determine the presence or absence of the pluripotent phenotype of embryonal carcinoma cells, and that coregulation of their quantities may serve some specific differentiation-associated function.
Permanent Link: http://hdl.handle.net/11104/0070622