0173447 - UEM-P 20010042 RIV NL eng J - Journal Article
Koskinen, M. - Vodička, Pavel - Hemminki, K.
Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA.
Chemico-Biological Interactions. Roč. 124, - (2000), s. 13-27. ISSN 0009-2797. E-ISSN 1872-7786
R&D Projects: GA ČR GA313/99/1460
Institutional research plan: CEZ:AV0Z5039906
Keywords : styrene oxide * DNA adducts
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 1.707, year: 2000

The results indicated that in double-stranded DNA N-7 of guanine and N-3 of adenine account for 97% of alkylation by SO. However, these abundant adducts are not stable, the half-life of depurination in DNA for 3-substituted adenines being ~ 10 and ~ 20 h, for ?- and ß-isomers, respectively, and 51 h for both isomers of 7-substituted guanines.
Permanent Link: http://hdl.handle.net/11104/0070480