Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors

Number of the records: 1

SYSNO ASEP	0172394
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors
Author(s)	Moravcová, Daniela (UEB-Q) Kryštof, Vladimír (UEB-Q)_{RID, ORCID} Havlíček, Libor (UEB-Q)_{RID, ORCID} Moravec, Jiří (UEB-Q) Lenobel, René (UEB-Q)_ORCID Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Source Title	Bioorganic and Medicinal Chemistry Letters. - : Elsevier - ISSN 0960-894X Roč. 13, č. 18 (2003), s. 2989ů2992
Number of pages	4 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Pyrazolo[4,3-d]pyrimidines ; CDK1/cyclin B ; anticancer agents
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA303/02/0875 GA ČR - Czech Science Foundation (CSF)
	KJB4038301 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z5038910 - UEB-Q
Annotation	A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2004

Number of the records: 1