0172322 - UEB-Q 20033047 RIV DE eng J - Journal Article
Hunkeler, D. - Vaňková, Radomíra
Cell Physiology and Interactions of Biomaterials and Matrices.
Polymer News. Roč. 28, č. 6 (2003), s. 193-197. ISSN 0032-3918
R&D Projects: GA MŠMT OC 840.20
Institutional research plan: CEZ:AV0Z5038910
Keywords : Biomaterials * Cell physiology * Encapsulation
Subject RIV: CE - Biochemistry

The effect of compression on Lactobacillus acidophilus was discussed. Their process includes the growth of bacteria, formulation, freeze drying, and compression to "encapsulate" cells. Cell viability remains above 90% with compression pressures of 60 MPa, though decreases strongly after application of 90 MPa. Cell viability has been lower for thicker coatings due to a higher resistance to rehydration. Overall, the total release time has varied from 5 to 9 hours, implying that this system could avoid cell release in the stomach and small intestines. Therefore, targeted cell delivery to the low intestines seems possible.
Permanent Link: http://hdl.handle.net/11104/0069361