0172265 - UEB-Q 20023050 RIV GB eng J - Journal Article
Maďarová, J. - Lukešová, M. - Hlobilková, A. - Strnad, Miroslav - Vojtěšek, B. - Lenobel, R. - Hajdúch, M. - Murray, P. G. - Perera, S. - Kolář, Z.
Synthetic inhibitors of CDKs induce different responses in androgen sensitive and androgen insensitive prostatic cancer cell lines.
Journal of Clinical Pathology - Molecular Pathology. Roč. 55, č. 4 (2002), s. 227-234. ISSN 1366-8714
R&D Projects: GA ČR GA301/02/0475
Institutional research plan: CEZ:AV0Z5038910
Keywords : synthetic CDK inhibitors * cell cycle * apoptosis
Subject RIV: EB - Genetics ; Molecular Biology

Because of the high prevalence of prostatic cancer and the limitations of its treatment, enormous effort has been put into the development of new therapeutic modalities. One potential tool is the use of cyclin dependent kinase (CDK) inhibitors, which are based on the trisubstituted derivatives of purine. The aim of this study was to analyse alterations of the regulatory pathways in both androgen sensitive and androgen insensitive prostatic cancer cell lines (LNCaP and DU-145, respectively) after blockage of the cell cycle by the synthetic CDK inhibitors, olomoucine and bohemine.
Permanent Link: http://hdl.handle.net/11104/0069304