0172221 - UEB-Q 20023003 RIV AT eng J - Journal Article
Franěk, František - Katinger, H.
Specific Effects of Synthetic Oligopeptides on Cultured Animal Cells.
Biotechnology Progress. Roč. 18, - (2002), s. 155-158. ISSN 8756-7938. E-ISSN 1520-6033
R&D Projects: GA MŠMT OC 844.10
Institutional research plan: CEZ:AV0Z5038910
Keywords : Oligopeptides * Animal Cells
Subject RIV: CE - Biochemistry
Impact factor: 1.734, year: 2002

Synthetic oligopeptides, tri- to pentaglycine and tri- and tetraalanine, were found to enhance viable cell density and culture viability when applied at concentrations higher than milllimolar to the cultures of a model hybridoma line. Oligoalanines, in addition, enhanced monoclonal antibody yields. Oligoglycines promoted solely the cell growth, unless the batch culture was fed with a medium concentrate. Examination of the effects of various tripeptides composed of glycine, alanine, serine, threonine, lysine, and histidine showed that some of the peptides promoted the growth of the culture, while other peptides suppressed the growth and enhanced the monoclonal antibody yield.
Permanent Link: http://hdl.handle.net/11104/0069260