0172220 - UEB-Q 20023002 RIV NL eng J - Journal Article
Franěk, František - Fismolová, Ivana - Eckschlanger, T.
Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells.
Archives of Biochemistry and Biophysics. Roč. 398, č. 1 (2002), s. 141-146. ISSN 0003-9861. E-ISSN 1096-0384
R&D Projects: GA MŠMT OC 844.10
Institutional research plan: CEZ:AV0Z5038910
Keywords : amino acids * MOLT-4 * apoptosis
Subject RIV: CE - Biochemistry
Impact factor: 2.606, year: 2002

This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect.
Permanent Link: http://hdl.handle.net/11104/0069259