0172204 - UEB-Q 20013083 RIV CZ eng J - Journal Article
Kryštof, V. - Strnad, Miroslav
Inhibitors of Cyclin-dependent Kinases.
Chemické listy. Roč. 95, č. 5 (2001), s. 295-300. ISSN 0009-2770. E-ISSN 1213-7103
R&D Projects: GA ČR GA301/02/0475; GA MŠMT VS96154
Institutional research plan: CEZ:AV0Z5038910
Keywords : Cyclin-dependent Kinase
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.317, year: 2001

Disorders in regulation mechanisms of the cell cycle cause uncontrolled division of cells, which is the nature of neoplastic diseases. Cyclin-dependent kinases (CDK), enzymes of the serine-threonine protein kinase group, belong to main regulators of cell division in all eukaryotic organisms. Their indispensibility in regulation of the cell cycle and, in particular, their frequent deregulation in tumours led to active search for chemical inhibitors of CDK. Butyrolactone, flavopiridol , purines of the olomoucin type, paullons, indirubins and others inhibit the CDK, stop the cell cycle in the G1/S and G2/M transitions and show interesting anticancer effects. In the article, chemical properties, the mechanism of action and biological activity of the inhibitors are described.
Permanent Link: http://hdl.handle.net/11104/0069246