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Chemical Probes in Biology. Science at the Interface of Chemistry, Biology and Medicine. NATO Science Series, II. Mathematics, Physics and Chemistry, Vol. 129

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    SYSNO ASEP0162527
    Document TypeM - Monograph Chapter
    R&D Document TypeMonograph Chapter
    TitleQuaternary benzo[c]phenanthridine alkaloids biological activities.Intracellular targets of their action and application in human and veterinary medicine
    Author(s) Šimánek, V. (CZ)
    Vespalec, Radim (UIACH-O)
    Šedo, A. (CZ)
    Ulrichová, J. (CZ)
    Vičar, J. (CZ)
    Source TitleChemical Probes in Biology. Science at the Interface of Chemistry, Biology and Medicine. NATO Science Series, II. Mathematics, Physics and Chemistry, Vol. 129 / Schneider M. P.. - Dordrecht : Kluwer Academic Publishers, 2003 - ISBN 1-4020-1769-3
    Pagess. 245-254
    Number of pages9 s.
    Languageeng - English
    CountryNL - Netherlands
    Keywordsbenzo[c]phenanthridine alkaloids ; sanguinarine ; chelerythrine
    Subject RIVCE - Biochemistry
    R&D ProjectsGA203/02/0023 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z4031919 - UIACH-O
    AnnotationThe article briefly reviewes information on the occurence of of benzo[c]phenanthridine alkaloids (QBA) in plats and on their chemical properties important from the viewpoint of QBA biological and biochemical activities. Than recent results of investigation of authors on QBA are presented: 1. Identification of chemical forms of sanguinarine and cheleryhtrine that complex with mercapto nuclophiles and the determination of stability constants that characterize their binding with human serum albumin;2. Inhibition effects of sanguinarine, cheleryhtrine and fagaronine on DPP-IV-like enzymes isolated from blood plasma and human and rat glinoma cell lines; and 3. QBA role in the genesis of epidemic dropsy syndrome.
    WorkplaceInstitute of Analytical Chemistry
    ContactIveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234
    Year of Publishing2004

Number of the records: 1  

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