0157568 - PAU-O 20023043 RIV CZ eng J - Journal Article
Pechová, Jitka - Tresová, Gabriela - Kovář, Lubomír - Kopecký, Jan
Tick salivary gland extract-activated transmission of Borrelia afzelii spirochaetes.
Folia Parasitologica. Roč. 49, č. 2 (2002), s. 153ů159. ISSN 0015-5683. E-ISSN 1803-6465
R&D Projects: GA ČR GA524/02/0901
Institutional research plan: CEZ:AV0Z6022909
Keywords : Ixodes ricinus * salivary gland extract * Borrelia afzelii
Subject RIV: EC - Immunology
Impact factor: 0.515, year: 2002

Saliva-activated transmission of Borrelia afzelii Canica, Nato, du Merle, Mazie, Baranton et Postic, 1993 was demonstrated using salivary gland extract (SGE) from Ixodes ricinus (L., 1758) ticks and C3H mice. Injection of Borrelia spirochaetes together with SGE increased the level of bacteraemia and accelerated the appearance of bacteria in the urinary bladder, compared with the injection of spirochaetes alone. More L ricinus nymphs became infected when feeding on mice inoculated with B. afzelii plus SGE. Analysis of cytokines produced by cells of draining lymph nodes from SGE-treated mice showed a suppression of proinflammatory cytokines IFN-gamma, IL-6 and GM-CSF following a transient upregulation in comparison with the control mice infected without SGE.
Permanent Link: http://hdl.handle.net/11104/0055006