0157567 - PAU-O 20023042 RIV DE eng J - Journal Article
Salát, Jiří - Braunfuchsová, Pavlína - Kopecký, Jan - Ditrich, Oleg
Role of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon intestinalis infection.
Parasitology Research. Roč. 88, č. 7 (2002), s. 603-608. ISSN 0932-0113. E-ISSN 1432-1955
R&D Projects: GA AV ČR IAA6022101
Institutional research plan: CEZ:AV0Z6022909
Keywords : immune-response * interferon-gamma * microsporidiosis
Subject RIV: EC - Immunology
Impact factor: 1.046, year: 2002

Severe combined immunodeficient (SCID) mice reconstituted with spleen cells from naive adult BALB/c mice were completely resistant to peroral infection with Encephalitozoon intestinalis (Calli, Kotler and Orenstein, 1993) Canning, Field, Hing and Marriott, 1994, whereas control, non-reconstituted SCID mice succumbed to the infection. The role of T-lymphocyte subpopulations in the protection against peroral E. intestinalis infection was studied In adoptive transfer experiments using SCID mice. SCID mice reconstituted with both CD4+ and CD8+ T-lymphocyte-depleted splenocytes succumbed to the peroral route of infection. In contrast, SCID mice reconstituted with either CD4+-depleted or CD8+ T-lymphocyte-depleted splenocytes completely resolved the infection. This indicates that CD4+ and CD8+ T-lymphocyte subpopulations play a substantive role in protection against peroral infection with the microsporidian, E. intestinalis.
Permanent Link: http://hdl.handle.net/11104/0055005