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Mass spectrometric analysis of recombinant adenylate cyclase toxin from Bordetella pertussis strain 18323/pHSP9+
- 1.0153846 - MBU-M 20010126 RIV GB eng J - Journal Article
Havlíček, Vladimír - Higgins, L. - Chen, W. - Halada, Petr - Šebo, Peter - Sakamoto, H. - Hackett, M.
Mass spectrometric analysis of recombinant adenylate cyclase toxin from Bordetella pertussis strain 18323/pHSP9+.
Journal of Mass Spectrometry. Roč. 36, - (2001), s. 384-391. ISSN 1076-5174. E-ISSN 1096-9888
R&D Projects: GA AV ČR IAA5020907; GA MŠMT ME 167; GA MŠMT VS96141
Institutional research plan: CEZ:A53/98:Z5-020-9ii
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.685, year: 2001
The adenylate cyclase toxin-hemolysin (ACT) is a key virulence factor of the whooping cough agent Bordetella pertussi (Bp.). The major cytotoxic activity of this 1706-residue protein consists of its capacity to invade a variety of eukaryotic cells directly across their cytoplasmic membrane and to deliver into cells a catalytic adenylate cyclase domain.
Permanent Link: http://hdl.handle.net/11104/0051338
Number of the records: 1