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Vascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall
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SYSNO ASEP 0142569 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Vascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall Author(s) Filová, Elena (FGU-C) RID, ORCID
Bačáková, Lucie (FGU-C) RID, ORCID
Lisá, Věra (FGU-C)
Machová, Luďka (UMCH-V) RID
Lapčíková, Monika (UMCH-V) RID
Kubies, Dana (UMCH-V) RID, ORCID
Proks, Vladimír (UMCH-V) RID, ORCID
Rypáček, František (UMCH-V) RIDSource Title Engineering of Biomaterials - ISSN 1429-7248
Roč. 6, - (2003), s. 9-11Number of pages 3 s. Action Konferencja Naukowa "Biomaterialy w medycynie i weterynarii" /13./ Event date 09.10.2003-12.10.2003 VEvent location Rytro Country PL - Poland Event type EUR Language eng - English Country PL - Poland Keywords tissue engineering ; bioactive polymers, RGD ; bioartificial vessel wall Subject RIV EI - Biotechnology ; Bionics R&D Projects IAA4050202 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LN00A065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z4050913 - UMCH-V AV0Z5011922 - FGU-C Annotation We focused on adhesion and spreading of vascular smooth muscle cells on lactide- and polyethylenoxide (PEO)-based polymers, materials for potential construction of vascular prostheses. On poly(DL-lactic acid), PDLLA, the number and spreading of initially attached rat aortic VSMC were similar as on standard cell culture plastics. However, the copolymer of PDLLA and PEO, MeO-PEO-b-PDLLA, almost disabled the cell adhesion and spreading. Grafting of GRGDSG peptide (in 5 or 20% concentration) to the copolymer restored the cell adhesion and spreading almost to the values found on PDLLA. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2004
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