Number of the records: 1  

Vascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall

  1. 1.
    SYSNO ASEP0142569
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JOstatní články
    TitleVascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall
    Author(s) Filová, Elena (FGU-C) RID, ORCID
    Bačáková, Lucie (FGU-C) RID, ORCID
    Lisá, Věra (FGU-C)
    Machová, Luďka (UMCH-V) RID
    Lapčíková, Monika (UMCH-V) RID
    Kubies, Dana (UMCH-V) RID, ORCID
    Proks, Vladimír (UMCH-V) RID, ORCID
    Rypáček, František (UMCH-V) RID
    Source TitleEngineering of Biomaterials - ISSN 1429-7248
    Roč. 6, - (2003), s. 9-11
    Number of pages3 s.
    ActionKonferencja Naukowa "Biomaterialy w medycynie i weterynarii" /13./
    Event date09.10.2003-12.10.2003
    VEvent locationRytro
    CountryPL - Poland
    Event typeEUR
    Languageeng - English
    CountryPL - Poland
    Keywordstissue engineering ; bioactive polymers, RGD ; bioartificial vessel wall
    Subject RIVEI - Biotechnology ; Bionics
    R&D ProjectsIAA4050202 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    LN00A065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    CEZAV0Z4050913 - UMCH-V
    AV0Z5011922 - FGU-C
    AnnotationWe focused on adhesion and spreading of vascular smooth muscle cells on lactide- and polyethylenoxide (PEO)-based polymers, materials for potential construction of vascular prostheses. On poly(DL-lactic acid), PDLLA, the number and spreading of initially attached rat aortic VSMC were similar as on standard cell culture plastics. However, the copolymer of PDLLA and PEO, MeO-PEO-b-PDLLA, almost disabled the cell adhesion and spreading. Grafting of GRGDSG peptide (in 5 or 20% concentration) to the copolymer restored the cell adhesion and spreading almost to the values found on PDLLA.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2004

Number of the records: 1  

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