Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques
1.
SYSNO ASEP
0142235
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques
Author(s)
Koistinaho, M. (US) Ort, Michael (FGU-C) Cimadevilla, Jose Maria (FGU-C) Vondrous, R. (CZ) Cordell, B. (CA) Koistinaho, J. (FI) Bureš, Jan (FGU-C) Higgins, L. (CA)
Source Title
Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences
- ISSN 0027-8424
Roč. 98, č. 4 (2001), s. 14675-14680
Number of pages
6 s.
Language
eng - English
Country
US - United States
Keywords
spatial memory ; transgenic mice ; alzheimer
Subject RIV
FH - Neurology
R&D Projects
GA309/00/1656 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z5011922 - FGU-C
Annotation
Transgenic mice expressing human beta-amyloid precursor protein were impaired in water maze navigation although they did not form plaques. The impairment increased with age from 3 to 24 months.
