0142060 - FGU-C 20000101 RIV US eng J - Journal Article
Pliss, Lioudmila - FitzGibbon, T. - Balcar, V. J. - Šťastný, František
Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands.
Neuroreport. Roč. 11, č. 16 (2000), s. 3651-3654. ISSN 0959-4965. E-ISSN 1473-558X
R&D Projects: GA ČR GA309/99/0211; GA AV ČR KSK2011602
Subject RIV: ED - Physiology
Impact factor: 2.696, year: 2000

The paper has two specific aims : (l) to investigate an ability ofintracerebroventricularly (ICV) infused NAAG to induce neurodegene-ration in subregions of rat hippocampal formation and (2) to test theability of NMDA receptor antagonists and mGluR ligands to prevent theneurotoxic actions of NAAG. NAAG-induced neurodegeneration is lesssevere than that induced by quinolinate and can be inhibited by NMDAreceptor antagnonists and also by an mGluR II agoinst, DCG IV.
Permanent Link: http://hdl.handle.net/11104/0039769