Isoforms of troponin in normal and diseased myocardium

0141974 - FGU-C 20000006 RIV CZ eng J - Journal Article
Adamcová, M. - Pelouch, Václav
Isoforms of troponin in normal and diseased myocardium.
Physiological Research. Roč. 48, č. 4 (1999), s. 235-247. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR GA305/98/P261
Subject RIV: ED - Physiology
Impact factor: 0.521, year: 1999

Troponin (Tn) is regulatory protein of myofibrills localized onactin filaments. Tn is composed from three subunits - TnT, TnCand TnI, each subunit exhibits specific biological role in musclefunction. During ontogenetic development of both cardiac and skeletalmuscles the synthesis of multiple isoforms of Tn was detected.Expression of Tn osoforms and their phosphorylation under patho-physiological situation (e.g. ischemia, congenital heart disease,heart failure) can affect the ATPase myofibrillar activity.
Permanent Link: http://hdl.handle.net/11104/0039689