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Role of beta-catenin in the developing cortical and hippocampal neuroepithelium
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SYSNO ASEP 0105365 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Role of beta-catenin in the developing cortical and hippocampal neuroepithelium Title Úloha beta-kateninu ve vyjíjejícím se kortikálním a hipokampálním epitelu Author(s) Machoň, Ondřej (UMG-J) RID
van den Bout, C. J. (NO)
Backman, M. (NO)
Kemler, R. (DE)
Krauss, S. (NO)Source Title Neuroscience. - : Elsevier - ISSN 0306-4522
Roč. 122, č. 1 (2003), s. 129-143Number of pages 15 s. Language eng - English Country US - United States Keywords cortex, catenin Subject RIV EB - Genetics ; Molecular Biology R&D Projects LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Annotation beta-Catenin plays a pivotal role in Wnt signaling during embryogenesis and is a component of adherens junctions. Since targeted disruption of the beta-catenin gene is lethal at gastrulation we have used a D6-Cre mouse line for conditional inactivation of beta-catenin in the mouse cerebral cortex and hippocampus after embryonic day (E) 10.5. In D6-Cre floxed beta-catenin mice, hippocampal CA1-CA2 fields are disrupted in similar manner as in Wnt-3a and LEF-1 mutants. The cortex of D6-Cre floxed beta-catenin mutants is strongly affected which contrasts with the normal cortex observed in Wnt-3a and LEF-1 mutants. Severe abnormalities in the organization of the neuroepithelium are observed that include disrupted interkinetic nuclear migration, loss of adherens junctions, impaired radial migration of neurons toward superficial layers and decreased cell proliferation after E15.5. At newborn stage, a premature disassembly of the radial glial scaffold and increased numbers of astrocytes are found in the cortex Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
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