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Genetic analysis of IgE expression
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SYSNO ASEP 0105315 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Genetic analysis of IgE expression Title Genetická analýza exprese IgE Author(s) Kosařová, Marcela (UMG-J)
Blažková, Hana (UMG-J)
Havelková, Helena (UMG-J)
Král, V. (CZ)
Lipoldová, Marie (UMG-J) RID, ORCIDSource Title Allergy. - : Wiley - ISSN 0105-4538
Roč. 57, Suppl.57 (2002), s. 140Number of pages 1 s. Action Congress of the European Academy of Allergology and Clinical Immunology EAACI /21./ Event date 01.06.2002-05.06.2002 VEvent location Neapol Country IT - Italy Event type EUR Language eng - English Country DK - Denmark Keywords gene ; QTL ; cytokine Subject RIV EC - Immunology R&D Projects GP310/02/P141 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5052915 - UMG-J Annotation Analysis of function of genes that control the expression of cytokines in health and disease. We have compared production of IL-4 and IL-10 in uninfected mice and in mice infected by Leishmania major and we have found that gene Cypr3 (cytokine production 3) influences cytokine expression both in uninfected and infected mice, whereas the influence of Cypr1 is restricted to certain conditions (uninfected mice). Cypr2 colocalizes with locus Lmr8 (Leishmania major response 8) on chromosome 1 that controls IgE production after L. major infection. These results might indicate either causal link between these two loci or that both functions are controlled by the same gene Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
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