Number of the records: 1
Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex
- 1.
SYSNO ASEP 0105299 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex Title Vazba inhibitoru na proteinové rozhraní v krystalu komplexu HIV-1 proteázy Author(s) Brynda, Jiří (UMG-J) RID
Řezáčová, Pavlína (UMG-J) RID
Fábry, Milan (UMG-J) RID
Hořejší, Magdalena (UMG-J)
Štouračová, Renata (UMG-J)
Souček, Milan (UOCHB-X)
Hradilek, Martin (UOCHB-X) ORCID
Konvalinka, Jan (UOCHB-X) RID, ORCID
Sedláček, Juraj (UMG-J) RIDSource Title Acta Crystallographica Section D-Biological Crystallography. - : WILEY-BLACKWELL - ISSN 0907-4449
11, D60, - (2004), s. 1943-1948Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords HIV-1 protease ; phenylnorstatine inhibitor ; crystal packing Subject RIV CE - Biochemistry R&D Projects LN00B030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5052915 - UMG-J Annotation Depending on the excess of ligand used for complex formation, the HIV-protease complexed with a novel phenylnorstatine inhibitor forms crystal either hexagonal (P6(1)) or orthorhombic (P2(1)2(1)) symetry. The orthorhombic form shows an unusual complexity of crystal packing: in addition to one inhibitor molecule that is bound to the enzyme active site, the second inhibitor molecule is bound as an outer ligand at the protein interface Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
Number of the records: 1