Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy. Rewiev article
1.
SYSNO ASEP
0105291
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy. Rewiev article
Title
Karbonická anhydráza IX (CA IX) jako potenciální cíl pro léčbu rakoviny. Přehledný článek
Author(s)
Pastoreková, S. (SK) Závada, Jan (UMG-J)
Source Title
Cancer Therapy
Roč. 2, - (2004), s. 245-262
Number of pages
17 s.
Language
eng - English
Country
GR - Greece
Keywords
cancer therapy ; carbonic anhydrase ; cell adhesion molecule
Subject RIV
EB - Genetics ; Molecular Biology
CEZ
AV0Z5052915 - UMG-J
Annotation
CA IX normally controls differentiation of gastric mucosa. Its abnormal expression is strongly associated with certain human tumors. It may serve as a target molecule for cancer therapy for the following reasons: it is expressed in various common carcinomas, resistant to conventional therapy; it is exposed on the cell surface; normally expressed CA IX in gastric mucosa has a limited access to immune cells, antibodies and many drugs
