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Mokrá granulace při výrobě léčiv
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SYSNO ASEP 0105033 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Mokrá granulace při výrobě léčiv Title High-Shear Wet Granulation Process in Drug Production Author(s) Bělohlav, Z. (CZ)
Břenková, L. (CZ)
Durdil, P. (CZ)
Hanika, Jiří (UCHP-M) RID, ORCID, SAI
Řápek, P. (CZ)
Tomášek, V. (CZ)
Lehocký, M. (CZ)Source Title Chemické listy. - : Česká společnost chemická - ISSN 0009-2770
Roč. 98, č. 12 (2004), s. 1146-1152Number of pages 7 s. Language cze - Czech Country CZ - Czech Republic Keywords granulation ; drug ; stirred granulators Subject RIV CI - Industrial Chemistry, Chemical Engineering CEZ AV0Z4072921 - UCHP-M Annotation Mokrá granulace při výrobě léčiv. Description in English The authors resume the most important knowledge on the mechanism, course and control of industrial wet granulation of pharmaceuticals in stirred granulators. Measurement of main impeller power input, conditions and consequences of heat transfer in granulation, sensitivity of the process to the shape and size of particles of active substance and transfer of data from a pilot-plant granulator to plant conditions are discussed more in detail. The most reliable method of monitoring the course of wet stirred granulation and for detection of the optimum state of granulated mixture is the measurement of main impeller power input. In addition to the input, also the batch temperature can be monitored which, however, depends more on the total time of stirring than on the actual state of the granulated mixture.The selection of an optimum amount of moisture and, subsequently, also the course of wet granulation are affected by the shape and size of particles of active substances. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2005
Number of the records: 1