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The effect of intestinal ischemia duration on changes in plasma antioxidant defense status in the rats
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SYSNO ASEP 0104729 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title The effect of intestinal ischemia duration on changes in plasma antioxidant defense status in the rats Title Vliv různé délky střevní ischemie na změny v antioxidačních obranných mechanismech v plasmě potkana Author(s) Čížová, Hana (BFU-R)
Lojek, Antonín (BFU-R) RID
Kubala, Lukáš (BFU-R) RID, ORCID
Číž, Milan (BFU-R) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 53, č. 5 (2004), s. 523-531Number of pages 9 s. Language eng - English Country CZ - Czech Republic Keywords antioxidants ; small intestine ; ischemia-reperfusion Subject RIV BO - Biophysics R&D Projects GA524/99/D022 GA ČR - Czech Science Foundation (CSF) GA524/01/1219 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5004920 - BFU-R Annotation Changes in antioxidative adaptive mechanisms induced by various periods of small intestinal ischemia was followed up in Wistar rats. The superior mesenteric artery was occluded for 15, 30, 45, 60 and 90 min and then the reperfusion was set for 120 min. Samples of the serum and intestinal mucosa were taken at the end of ischemia or reperfusion. Enhaced activity of circulating neutrophils ater the reperfusion was irrespective of the duration of ischemia. The ischemia of rat small intestine enhanced the activity of natural antioxidant mechanisms of the serum depending on the duration of ischemia and the presence or absence of subsequent reperfusion. Contrary to the mobilized antioxidative mechanisms, increased lipid peroxidation was observed in serum and mucosa samples. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2005
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