Number of the records: 1
Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells
- 1.
SYSNO ASEP 0104653 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells Překlad názvu Polycyklické aromatické uhlovodíky modulují proliferaci krysích jaterních epiteliálních „kmenových“ buněk WB-F344 Tvůrce(i) Chramostová, Kateřina (BFU-R)
Vondráček, Jan (BFU-R) RID, ORCID
Šindlerová, Lenka (BFU-R) RID, ORCID
Vojtěšek, B. (CZ)
Kozubík, Alois (BFU-R) RID, ORCID
Machala, M. (CZ)Zdroj.dok. Toxicology and Applied Pharmacology. - : Elsevier - ISSN 0041-008X
Roč. 196, č. 1 (2004), s. 136-148Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova polycyclic aromatic hydrocarbons ; contact inhibition ; rat liver epithelial cells Vědní obor RIV BO - Biofyzika CEP GP525/01/D076 GA ČR - Grantová agentura ČR GA525/03/1527 GA ČR - Grantová agentura ČR CEZ AV0Z5004920 - BFU-R Anotace Although many polycyclic aromatic hydrocarbons (PAHs) are recognized as potent mutagens and carcinogens, relatively little is known about their role in the tumor promotion. It is known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce release of rat hepatic oval epithelial cells from contact inhibition by a mechanism possibly involving the aryl hydrocarbon receptor (AhR) activation. Many PAHs are AhR ligands and are known to act as transient inducers of AhR-mediated activity. In this study, effects of 19 selected PAHs on proliferation of confluent rat liver epithelial WB-F344 cells were investigated. The results of the present study seem to suggest that a release from contact inhibition could be a part of tumor promoting effects of AhR-activating PAHs; however, the genotoxic effects of some PAHs associated with p53 activation might interfere with this process. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2005
Number of the records: 1