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Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells
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SYSNO ASEP 0104634 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells Title Jaderná topografie beta-like globinového klastru genů u lidských leukemických buněk stimulovaných IL-3 Author(s) Galiová-Šustáčková, Gabriela (BFU-R)
Bártová, Eva (BFU-R) ORCID
Kozubek, Stanislav (BFU-R) RIDSource Title Blood Cells Molecules and Diseases. - : Elsevier - ISSN 1079-9796
Roč. 33, č. 1 (2004), s. 4-14Number of pages 11 s. Language eng - English Country US - United States Keywords beta-like globin gene cluster ; K-562 cells ; nuclear topography Subject RIV BO - Biophysics R&D Projects GA301/01/0186 GA ČR - Czech Science Foundation (CSF) KSK5052113 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA5004306 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA202/04/0907 GA ČR - Czech Science Foundation (CSF) ME 565 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5004920 - BFU-R Annotation Interleukin-3 (IL-3) stimulated human leukemic K 562 cells were used as a model system in which nuclear organization and expression of the beta-like globin gene cluster was investigated. Conserved nuclear location of beta-like globin gene clusters was found in both control and IL-3 treated cells, which indicates that changes in cluster gene expression are associated with a stable nuclear topography. The studied type of cell differentiation was characterized by relocation of chromosome 11 and its centromeric regions closer to the nuclear periphery, which seems to be a general feature of many pathways of cellular maturation. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2005
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