Experimental infection of severe combined immunodeficient (SCID) mice with the human microsporidian Trachipleistophora hominis
1.
SYSNO ASEP
0104442
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Experimental infection of severe combined immunodeficient (SCID) mice with the human microsporidian Trachipleistophora hominis
Title
Experimentální infekce SCID myší lidskou mikrosporidií Trachipleistophora hominis
Author(s)
Koudela, Břetislav (PAU-O) Vávra, Jiří (PAU-O) Canning, E. U. (GB)
Source Title
Parasitology. - : Cambridge University Press
- ISSN 0031-1820
Roč. 128, č. 4 (2004), s. 377-384
Number of pages
8 s.
Language
eng - English
Country
GB - United Kingdom
Keywords
microsporidia ; Trachipleistophora hominis ; experimental infection
Subject RIV
EE - Microbiology, Virology
CEZ
AV0Z6022909 - PAU-O, BC-A
Annotation
Different courses of microsporidiosis, related to the route of infection, were observed in severe combined immunodeficient (SCID) mice inoculated with spores of the human microsporidian Trachipleistophora hominis (Phylum Microspora). Mice were inoculated by eye contamination by spores and intramuscular, subcutaneous intracerebral, intraperitoneal and peroral inoculation. Our results show that T. hominis has very little tissue specificity. Peroral infection seems to be ineffective in T. hominis, but eye contamination or insect bite (as mimicked by injection) are suggested as possible routes of infection under natural conditions
