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Experimental infection of severe combined immunodeficient (SCID) mice with the human microsporidian Trachipleistophora hominis

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    0104442 - PAU-O 20043020 RIV GB eng J - Journal Article
    Koudela, Břetislav - Vávra, Jiří - Canning, E. U.
    Experimental infection of severe combined immunodeficient (SCID) mice with the human microsporidian Trachipleistophora hominis.
    [Experimentální infekce SCID myší lidskou mikrosporidií Trachipleistophora hominis.]
    Parasitology. Roč. 128, č. 4 (2004), s. 377-384. ISSN 0031-1820. E-ISSN 1469-8161
    Institutional research plan: CEZ:AV0Z6022909
    Keywords : microsporidia * Trachipleistophora hominis * experimental infection
    Subject RIV: EE - Microbiology, Virology
    Impact factor: 1.685, year: 2004

    Different courses of microsporidiosis, related to the route of infection, were observed in severe combined immunodeficient (SCID) mice inoculated with spores of the human microsporidian Trachipleistophora hominis (Phylum Microspora). Mice were inoculated by eye contamination by spores and intramuscular, subcutaneous intracerebral, intraperitoneal and peroral inoculation. Our results show that T. hominis has very little tissue specificity. Peroral infection seems to be ineffective in T. hominis, but eye contamination or insect bite (as mimicked by injection) are suggested as possible routes of infection under natural conditions

    Průběh infekce ve vztahu cestám inokulace byly sledovány u severe combined immunodeficient (SCID) myší infikovaných lidskou mikrosporidií Trachipleistophora hominis (Phylum Microspora). Myši byly inokulovány intraokulární, intramuskulární, subkutánní, intracerebrální a orální cestou. Výsledky ukazují nízkou tkáňovou specifičnost T. hominis. Perorální infekce se zdá být neefektivní, ale intraconjunktivální a injekční cesta jsou zřejmě cestami infekce v přirozených podmínkách
    Permanent Link: http://hdl.handle.net/11104/0011708

     
     

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