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The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells
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SYSNO ASEP 0104207 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells Title Vliv chemické struktury alifatických polyesterů na adhesi a růst osteoblastických buněk MG 63 Author(s) Pamula, E. (PL)
Bačáková, Lucie (FGU-C) RID, ORCID
Buczynska, J. (PL)
Filová, Elena (FGU-C) RID, ORCID
Nosková, Lenka (FGU-C)
Dobrzynski, P. (PL)
Bero, M. (PL)Source Title Engineering of Biomaterials - ISSN 1429-7248
Roč. 7, č. 37 (2004), s. 14-17Number of pages 4 s. Action Konferencja Naukowa Biomaterialy w medycynie i weterynarii /14./ Event date 10.10.2004-13.10.2004 VEvent location Rytro Country PL - Poland Event type EUR Language eng - English Country PL - Poland Keywords tissue engineering ; degradable copolymers ; physicochemical surface properties Subject RIV EI - Biotechnology ; Bionics R&D Projects OC 527.130 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5011922 - FGU-C Annotation Degradable copolymers of glycolide and L-lactide (PGLA), glycolide and epsilon-caprolactone (PGCap) and terpolymer of glycolide, L-lactide and epsilon-caprolactone (PGLCap) were synthesized by ring opening polymerization and their interaction with osteoblast-like MG63 cells was tested in vitro. the cell behaviour on PGLA and PGLCap was very similar as on control tissue culture polystyrene (TCPS). On PGCap, however, the number of initially adhering cells was significantly lower (by 84% than on TCPS) and cell spreading area smaller (by 50%). On day 7 after seeding, these cells also reached the lowest populaton density. We hypothesize that the lower cell adhesion and growth of MG63 cells on PGCap was caused by the highest hydrophobicity of this material among all studied samples. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2005
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