0102878 - UOCHB-X 20043344 RIV US eng J - Journal Article
Balzarini, J. - Pannecouque, C. - Naesens, L. - Andrei, G. - Snoeck, R. - De Clercq, E. - Hocková, Dana - Holý, Antonín
6-[2-(Phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: A new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
[6-[2-(Fosfonomethoxy)alkoxy]-2,4-diaminopyrimidiny: nová třída pyrimidinových acyklických nukleosidfosfonátů s protivirovým účinkem.]
Nucleosides Nucleotides & Nucleic Acids. Roč. 23, 8/9 (2004), s. 1321-1327. ISSN 1525-7770. E-ISSN 1532-2335
R&D Projects: GA AV ČR IBS4055109
Grant - others:GWOV(BE) G.0104.98; GOA(BE) 00/12
Institutional research plan: CEZ:AV0Z4055905
Keywords : herpesviruses * poxviruses * hepadnaviruses
Subject RIV: CC - Organic Chemistry
Impact factor: 0.429, year: 2004

Acyclic nucleoside phosphonate derivatives containing a pyrimidine base preferably bearing amino groups at C-2 and C-4 and linked at the C-6 position to (S)-[3-hydroxy-2-(phosphonomethoxy)-propoxy], 2-(phosphonomethoxy)ethoxy or (R)-[2-(phosphonomethoxy)proxy] (PMPO), display an antiviral spectrum closely mimicking that of the parental (S)-HPMP-, PME- and (R)-PMP- purine derivatives

Acyclické nukleosidfosfonáty pyrimidinů substituovaných aminoskupinami v C-2 a C-4 navázanými linked at the C-6 position to (S)-[3-hydroxy-2-(fosfonomethoxy)-propoxy], 2-(fosfonomethoxy)ethoxy or (R)-[2-(fosfonomethoxy)propoxy mají spektrum účinků paraátů purinů
Permanent Link: http://hdl.handle.net/11104/0010215