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Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
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SYSNO ASEP 0102560 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Title Odhalení telmisartanu jako unikátního antagonisty angiotensin II receptoru se selektivní modulační aktivitou Pparg Author(s) Benson, S. C. (US)
Pershadsingh, H. A. (US)
Ho, C. I. (US)
Chittiboyina, A. (US)
Desai, P. (US)
Pravenec, Michal (FGU-C) RID, ORCID
Qi, N. (US)
Wang, J. (US)
Avery, M. A. (US)
Kurtz, T. W. (US)Source Title Hypertension. - : Lippincott Williams & Wilkins - ISSN 0194-911X
Roč. 43, č. 5 (2004), s. 993-1002Number of pages 10 s. Language eng - English Country US - United States Keywords receptors ; insulin resistance ; losartan Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/01/0278 GA ČR - Czech Science Foundation (CSF) LN00A079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5011922 - FGU-C Annotation We found that telmisartan, a structurally unique angiotensin II receptor antagonist used for the treatment of hypertension, can function as a partial agonist of the peroxisome proliferator activated receptor gamma (PPARgamma), influence the expression of PPARgamma target genes involved in carbohydrate and lipid metabolism, and reduce glucose, insulin, and triglyceride levels in rats fed a high fat, high carbohydrate diet Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2005
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