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Application of a novel Active Allothetic Place Avoidance task (AAPA) in testing a pharmacological model of psychosis in rats: comparison with the Morris Water Maze
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SYSNO ASEP 0102535 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Application of a novel Active Allothetic Place Avoidance task (AAPA) in testing a pharmacological model of psychosis in rats: comparison with the Morris Water Maze Title Použití nové úlohy aktivního alotetického vyhýbání se místu (AAPA) v testování farmakologického modelu psychózy: srovnáni s Morrisovým vodním bludištěm Author(s) Stuchlík, Aleš (FGU-C) RID, ORCID
Řezáčová, Lenka (FGU-C) RID, ORCID, SAI
Valeš, Karel (FGU-C) RID, ORCID, SAI
Bubeníková, V. (CZ)
Kubík, Štěpán (FGU-C) RID, ORCIDSource Title Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 366, č. 2 (2004), s. 162-166Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords cognition ; dizocilpine ; schizophrenia Subject RIV FH - Neurology R&D Projects GP309/03/P126 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5011922 - FGU-C Annotation Administration of a non-competitive NMDA antagonist dizocilpine (MK-801) was proposed to be an animal model of psychosis. However, the role of NMDA-receptors in organizing brain representations is not understood yet. We tested the effect of NMDA-receptor blockade by systemic administration of dizocilpine at two different doses (0.1 mg/kg or 0.2 mg/kg) in a recently designed Active Allothetic Place Avoidance, a task which requires rats to separate spatial stimuli from two continuously dissociated subsets. The effect of dizocilpine on learning in the AAPA task was compared with its effect on acquisition of the reference memory version of the Morris Water Maze task. Both doses impaired performance in the Morris Water Maze task, whereas only the higher dose impaired performance in the AAPA task. The Morris Water Maze appears to be more sensitive to dizocilpine-induced behavioral deficit than the AAPA task Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2005
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