0101982 - UOCHB-X 20043246 RIV CZ eng J - Journal Article
Černý, Ivan - Havlíková, H. - Hill, M. - Hampl, R. - Pouzar, Vladimír
Synthetic approach to 5alpha-pregnanolone 19-[O-(carboxymethyl)oxime]derivatives.
[Syntetický přístup k 19-[O-(karboxymethyl)oxim]derivátům 5alfa-pregnanolonů.]
Collection of Czechoslovak Chemical Communications. Roč. 69, č. 9 (2004), s. 1805-1817. ISSN 0010-0765
R&D Projects: GA ČR GA203/04/0123
Institutional research plan: CEZ:AV0Z4055905
Keywords : synthesis * steroids * neurosteroids
Subject RIV: CC - Organic Chemistry
Impact factor: 1.062, year: 2004

Synthesis of 5alpha-pregnanolone derivatives (3-hydroxy-5alpha-pregnan-20-ones) with 3alpha- and 3beta-configuration and 19-[O-(carboxymethyl)oxime] group were developed, starting from 19-hydroxy-20-oxopregn-5-en-3beta-yl acetate. The nine- and ten-step syntheses described herein gave the target compounds, designed as haptens for immunological use

Byla vypracována synthesa 5alfa-pregnanolonových derivativátů (3-hydroxy-5alfa-pregnan-20-ony) s 3alfa- a 3beta-konfigurací a 19-[O-(karboxymethyl)oxim]ovou skupinou, vycházející z 19-hydroxy-20-oxopregn-5-en-3beta-yl acetátu. Popsané devíti a desítistupňové syntézy poskytly cílové látky, určené jako hapteny s použitím v imunologii
Permanent Link: http://hdl.handle.net/11104/0009345