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Antibody-targeted polymer-doxorubicin conjugates with enzyme or pH-controlled activation
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SYSNO ASEP 0101342 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Antibody-targeted polymer-doxorubicin conjugates with enzyme or pH-controlled activation Title Protilátkou cílené konjugáty polymer-doxorubicin s enzymem nebo pH kontrolovanou aktivací Author(s) Ulbrich, Karel (UMCH-V) RID
Šubr, Vladimír (UMCH-V) RID, ORCID
Strohalm, Jiří (UMCH-V)
Etrych, Tomáš (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Kovář, Marek (MBU-M) RID, ORCID
Jelínková, Markéta (MBU-M)
Říhová, Blanka (MBU-M) RIDSource Title Congress Proceedings. - Paris : International Union of Pure and Applied Chemistry, 2004 Pages 5.3.3.1-5.3.3.2 Number of pages 2 s. Publication form www, CD ROM - www, CD ROM Action IUPAC International Symposium on Macromolecules, World Polymer Congress MACRO /40./ Event date 04.07.2004-09.07.2004 VEvent location Paris Country FR - France Event type WRD Language eng - English Country FR - France Keywords polymer-drug conjugates ; pH-controlled activation ; doxorubicin Subject RIV CD - Macromolecular Chemistry R&D Projects IBS5020101 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA4050201 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA305/02/1425 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z4050913 - UMCH-V Annotation Various structures of polymer carriers and polymer drugs were synthesized and studied. Synthesis of antibody-targeted polymer-doxorubicin conjugates differing in the structure of the polymer carrier and the mechanism of drug release was elaborated. During the treatment with polymer-doxorubicin conjugates, the immune system of treated mice is activated and an effective long-term anti-tumor immunity is established. Antibody-targeted polymer drugs are thus promising candidates for effective cancer treatment. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2005
Number of the records: 1