0101289 - UMCH-V 20043009 RIV GB eng C - Conference Paper (international conference)
Šubr, Vladimír - Ulbrich, Karel
Synthesis of HPMA-DOX-antibody conjugates. Optimization of antibody-binding reaction of a polyHPMA procursor containing thiazolidine-2-thione reactive groups.
[Syntéza konjugátů HPMA-DOX-protilátka. Optimalizace vazebné reakce protilátky s polyHPMA prekurzorem obsahujícím thiazolidin-2-thionové reaktivní skupiny.]
From Laboratory to Clinical Practice. Cardiff: Welsh School of Pharmacy, Redwood Building, Cardiff University, 2004, s. 46.
[International Symposium on Polymer Therapeutics /6./. Cardiff (GB), 07.01.2004-09.01.2004]
R&D Projects: GA AV ČR IBS5020101
Institutional research plan: CEZ:AV0Z4050913
Keywords : polymer-drug-antibody conjugates * thiazolidine-2-thione reactive polymers
Subject RIV: CD - Macromolecular Chemistry

The goal of this work was to optimize the reaction conditions of the synthesis of HPMA-DOX-antibody conjugates, such as content of reactive groups in side chains, polymer/antibody ratio, reaction time and pH.

V práci byly optimalizovány reakční podmínky syntézy konjugátů HPMA/DOX/protilátka, a to obsah reaktivních skupin v postranních řetězcích, poměr polymer/protilátka, reakční doba a pH.
Permanent Link: http://hdl.handle.net/11104/0008723