0100884 - UOCHB-X 20043072 RIV GB eng J - Journal Article
Otmar, Miroslav - Masojídková, Milena - Votruba, Ivan - Holý, Antonín
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds.
[Syntéza a antiproliferativní účinky 2,6-diamino-9-benzyl-9-deazapurinu a odvozených sloučenin.]
Bioorganic & Medicinal Chemistry. Roč. 12, č. 12 (2004), s. 3187-3195. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT 1P04OCD13.20
Institutional research plan: CEZ:AV0Z4055905
Keywords : tautomerism * C-alkylation * reductive cyclization
Subject RIV: CC - Organic Chemistry
Impact factor: 2.018, year: 2004

A series of 9-deazapurine-2,6-diamines bearing benzyl groups in positions N2, N6, and 9 was synthetized. Among them, 9, N2,N6-tribenzyl-9-deazapurine-2,6-diamine exhibited the best antiproliferative activity on CCRF-CEM, HL-60, HeLa S3, and L1210 cells: IC50 = 1.9, 2.7, 7.3, and 1.0 micromol/L

Byla syntetizována série 9-deazapurin-2,6-diaminů nesoucích benzylové skupiny v polohách N2, N6 a 9. Z nich měl nejlepší antiproliferativní aktivitu 9,N2,N6-tribenzyl-9-deazapurin-2,6-diamin na buňkách CCRF-CEM, HL-60, HeLa S3 a L1210: IC50 = 1,9; 2,7; 7,3 a 1,0 mikromol/l
Permanent Link: http://hdl.handle.net/11104/0008368