0100860 - UOCHB-X 20043048 RIV GB eng J - Journal Article
Hocková, Dana - Holý, Antonín - Masojídková, Milena - Andrei, G. - Snoeck, R. - De Clercq, E. - Balzarini, J.
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds.
[Syntéza a protivirová aktivita 2,4-diamino-5-kyano-6-[2-(fosfonomethoxy)ethoxy]pyrimidinu a příbuzných sloučenin.]
Bioorganic & Medicinal Chemistry. Roč. 12, č. 12 (2004), s. 3197-3202. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA AV ČR IBS4055109
Grant - others:ISEP/FORTIS(US) GOA-00/12; European Commission(XE) HPAW-2002-90001
Institutional research plan: CEZ:AV0Z4055905
Keywords : nucleotide analogues * antiviral * pyrimidines
Subject RIV: CC - Organic Chemistry
Impact factor: 2.018, year: 2004

Synthesis of 2,4-diamino-5-cyano-6-{[(diisopropoxyphosphoryl)methoxy]ethoxy}pyrimid ine was based on the formation of the pyrimidine ring by cyclization followed by modification of the side chain by alkylation. The 5-cyano group was also transformed to a 5-formyl and 5-hydroxymethyl group by reduction. Some derivatives showed pronounced antiretroviral activity

Syntéza a protivirová aktivita 2,4-diamino-5-kyano-6-[2-(fosfonomethoxy)ethoxy]pyrimidinu je zaĺožena na tvorbě pyrimidinového kruhu cyklizací a následující alkylací. 5-kyanoskupina byla dáĺe převedena na formyl a 5-hydroxymethylskupinu redukcí. Některé z těchto látek mají protiretrovirový účinek
Permanent Link: http://hdl.handle.net/11104/0008346