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The adenylate cyclase toxin from Bordetella pertussis - a novel promising vehicke fer antigen delivery to dendritic cells
- 1.0100395 - MBU-M 20040085 RIV DE eng J - Journal Article
Šimšová, Marcela - Šebo, Peter - Leclerc, C.
The adenylate cyclase toxin from Bordetella pertussis - a novel promising vehicke fer antigen delivery to dendritic cells.
[Adenylátcyklasový toxin z Bordetella pertussis – nový perspektivní vektor pro dopravu antigenů do dendritických buněk.]
International Journal of Medical Microbiology. Roč. 293, - (2004), s. 571-576. ISSN 1438-4221. E-ISSN 1618-0607
R&D Projects: GA ČR GA310/01/0934; GA AV ČR IAA5020907
Grant - others:GA QLK2-CT-1999(XX) 00556
Keywords : cyaa * cellular immune response * antigen delivery
Subject RIV: EE - Microbiology, Virology
Impact factor: 2.919, year: 2004
Bordetella pertussis secretes an adenylate cyclase toxin that targets primarily cells expressing the alphaMbeta2 integrin (CD11b/CD18) receptor. Various heterologous CD8+, as well as CD4+ T-cell epitopes have been engineered into genetically detoxified CyaA and the resulting toxoids were successfully used as vectors for delivery of inserted epitopes into antigen-presenting cells.
Přehledný článek pojednává o využití ACT jako nového nosiče pro dopravu antigenů do dendritických buněk a indukci specifických imunitních odpovědí.
Permanent Link: http://hdl.handle.net/11104/0007897
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