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Lincomycin, clindamycin and their applications
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SYSNO ASEP 0100373 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Lincomycin, clindamycin and their applications Title Linkomycin, klindamycin a jejich aplikace Author(s) Spížek, Jaroslav (MBU-M)
Řezanka, Tomáš (MBU-M) ORCIDSource Title Applied Microbiology and Biotechnology. - : Springer - ISSN 0175-7598
Roč. 64, - (2004), s. 455-464Number of pages 10 s. Language eng - English Country DE - Germany Keywords streptomyces lincolnensis Subject RIV EE - Microbiology, Virology R&D Projects GA204/01/1004 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5020903 - MBU-M Annotation Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may even be bactericidal at the higher concentrations that can be reached in vivo . Clindamycin is usually more active than lincomycin in the treatment of bacterial infections, in particular those caused by anaerobic species; and it can also be used for the treatment of important protozoal diseases, e.g. malaria, most effectively in combination with primaquine. Resistance to lincomycin and clindamycin may be caused by methylation of 23S ribosomal RNA, modification of the antibiotics by specific enzymes or active efflux from the periplasmic space. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2005
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