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Chondrocytic potential of allogenic mesenchymal stem cells transplanted without immunosuppression to regenerate physeal defect in rabbits
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SYSNO ASEP 0097981 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Chondrocytic potential of allogenic mesenchymal stem cells transplanted without immunosuppression to regenerate physeal defect in rabbits Title Chondrogenní potenciál allogenních mezenchymových kmenových buněk transplantovaných bez imunosuprese k regeneraci fyzárních defektů u králíků Author(s) Gál, P. (CZ)
Nečas, A. (CZ)
Plánka, L. (CZ)
Kecová, H. (CZ)
Křen, L. (CZ)
Krupa, P. (CZ)
Hlučilová, Jana (UZFG-Y) RID, ORCID
Usvald, Dušan (UZFG-Y)Source Title Acta veterinaria Brno. - : Veterinární a farmaceutická univerzita Brno - ISSN 0001-7213
Roč. 76, - (2007), s. 265-275Number of pages 11 s. Language eng - English Country CZ - Czech Republic Keywords growth plate injury ; bone bridge ; limb deformity Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine R&D Projects 2B06130 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50450515 - UZFG-Y (2005-2011) Annotation Mesenchymal stem cells (MSCs) from bone marrow are multipotent cells capable of forming cartilage, bone, and other connective tissues. The objective of this study was to determine whether the use of allogenic mesenchymal stem cells could functionally heal a defect in the distal femoral physis in rabbits without the use of immunosuppressive therapy.The results of this study demonstrated that allogenic mesenchymal stem cells in a new composite hyaluronate/collagen type I/fibrin scaffold repaired iatrogenic defects in the distal femoral physes in rabbits without the use of immunosuppressive therapy. The use of allogenic mesenchymal stem cells for the repair of physeal defects may be an alternative to autologous MSCs transplantation. An allogenic approach would enable mesenchymal stem cells to be isolated from any donor, providing a readily available source of cells for cartilage tissue repair. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2008
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