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Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines
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SYSNO ASEP 0092546 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines Title Bifunkční acycklické nukleosidové fosfonáty: Syntéza chirálních 9-{3-hydroxy[1,4-bis(fosfonomethoxy)]butan-2-yl} purinových derivátů Author(s) Vrbková, Silvie (UOCHB-X)
Dračínský, Martin (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)Source Title Tetrahedron Asymmetry. - : Elsevier - ISSN 0957-4166
Roč. 18, č. 18 (2007), s. 2233-2247Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords acyclic nucleoside phosphonates ; acyclic nucleoside bisphosphonates ; phosphonomethyl ethers ; purines Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) DOI 10.1016/j.tetasy.2007.09.021 Annotation We report here a general method for the synthesis of new type of chiral acyclic nucleoside four-carbon bisphosphonates, (2S,3S) or (2R,3R)-9-{3-(hydroxy)-1,4-[bis(phosphonomethoxy]butan-2-yl} derivative of purines respectively. L-Threitol and D-mannitol were used as the source of chirality. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2008
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