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Transgenic UCP1 in white fat protects against lipid accumulation in skeletal muscle of mice fed a high-fat diet
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SYSNO ASEP 0091702 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Transgenic UCP1 in white fat protects against lipid accumulation in skeletal muscle of mice fed a high-fat diet Title Transgenní UCP1 v bílé tukové tkáni zabraňuje akumulaci lipidů v kosterním svalu myší, krmených vysokotukou dietou Author(s) Jeleník, Tomáš (FGU-C)
Jílková, Zuzana (FGU-C)
Slámová, Kristýna (FGU-C)
Rossmeisl, Martin (FGU-C) RID, ORCID
Kopecký, Jan (FGU-C) RID, ORCIDSource Title Diabetologia - ISSN 0012-186X
Roč. 50, Suppl.1 (2007), S321-S321Number of pages 1 s. Action Annual Meeting of the European Association for the Study of Diabetes /43./ Event date 18.09.2007-21.09.2007 VEvent location Amsterdam Country NL - Netherlands Event type EUR Language eng - English Country DE - Germany Keywords cpo1 ; respiratory uncoupling ; white fat ; lipid metabolism Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects GD303/03/H065 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) Annotation Respiratory uncoupling, brought about by transgenic UCP1 white fat, limited the accumulation of triglyceriges in skeletal muscle and liver, while improving glucose tolerance in mice fed a high-fat diet. In skeletal muscle, these changes were asociated with a simultaneous inhibition of lipogenesis and induction of respiration.The enhancement of energy expenditure in muscle, in response tu a lower release of fatty acids from white fat, may contribute to both, obesity-resistence and insulin sensitivity of the aP2-UCP1 transgenic mice Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2008
Number of the records: 1