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The telomere repeat motif of basal Metazoa
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SYSNO ASEP 0080761 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title The telomere repeat motif of basal Metazoa Title Repetitivní motiv telomer u bazálních skupin mnohobuněčných živočichů (Metazoa) Author(s) Traut, W. (DE)
Szczepanowski, M. (DE)
Vítková, Magda (BC-A) RID
Opitz, Ch. (DE)
Marec, František (BC-A) RID, ORCID
Zrzavý, Jan (BC-A)Source Title Chromosome Research. - : Springer - ISSN 0967-3849
Roč. 15, č. 3, (2007), s. 371-382Number of pages 12 s. Language eng - English Country NL - Netherlands Keywords ancestral telomere ; Choanozoa ; Cnidaria Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA206/06/1860 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) Annotation In most eukaryotes the telomeres consist of short DNA tandem repeats and associated proteins. Telomeric repeats are added to the chromosome ends by telomerase, a specialized reverse transcriptase. We examined telomerase activity and telomere repeat sequences in representatives of basal metazoan groups. Our results show that the "vertebrate" telomere motif (TTAGGG)n is present in all basal metazoan groups, i.e. sponges, Cnidaria, Ctenophora, and Placozoa, and also in the unicellular metazoan sister group, the Choanozoa. Thus it can be considered the ancestral telomere repeat motif of Metazoa. It has been conserved from the metazoan radiation in most animal phylogenetic lineages, and replaced by other motifs -according to our present knowledge - only in two major lineages, Arthropoda and Nematoda. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2007
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