Number of the records: 1
Colonic bacteria enhance the development of apoptosis resistance, which may increase the risk of colon cancer
- 1.
SYSNO ASEP 0025596 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Colonic bacteria enhance the development of apoptosis resistance, which may increase the risk of colon cancer Title Apoptosa v tkáni tlustého střeva je snížena pod vlivem střevních bakterií, což má za následek zvýšený výskyt nádorů tlustého střeva Author(s) Wilson, M. A. (US)
Štěpánková, Renata (MBU-M) RID
Holubec, H. (US)
Payne, C. (US)
Vannucci, Luca (MBU-M) RID, ORCID
Bernstein, H. (US)
Bernstein, C. (US)
Garewal, H. (US)
Dvorakova, K. (US)Source Title Annual Meeting /96./. - Anaheim, 2005 Pages s. 15-15 Number of pages 1 s. Action Annual Meeting /96./ Event date 16.04.2005-20.04.2005 VEvent location Anaheim Country US - United States Event type WRD Language eng - English Country US - United States Keywords apoptosis ; colonic bacteria Subject RIV EE - Microbiology, Virology CEZ AV0Z50200510 - MBU-M (2005-2011) Annotation Hydrophobic bile acids, such as deoxycholic acid (DOC), induce apoptosis, DNA damage and oxidative stress. Wistar rats were raised in germ-free or conventional conditions. Colon cancer was initiated by application of azoxymethan intra muscular and bile directly in surgically created cecal hernia. Apoptosis was detected immunohistochemically using antibodies against cleved caspase-3. Higher incidence of colon tumors was in the conventional compare to germ-free rats. Normal appearing mucosa from conventional rats was more resistant to apoptosis induced by DOC than mucosa from germ-free rats Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2006
Number of the records: 1