Number of the records: 1  

Effect of probiotic bacteria and the routes of mucosal application on the severity

  1. 1.
    SYSNO ASEP0025570
    Document TypeC - Proceedings Paper (int. conf.)
    R&D Document TypeConference Paper
    TitleEffect of probiotic bacteria and the routes of mucosal application on the severity
    TitleVliv probiotických bakterií a způsob jejich podávání na experimentálně indukované intestinální záněty u myší
    Author(s) Hudcovic, Tomáš (MBU-M) RID, ORCID
    Štěpánková, Renata (MBU-M) RID
    Hrnčíř, Tomáš (MBU-M) RID, ORCID
    Kozáková, Hana (MBU-M) RID, ORCID
    Erban, V. (CZ)
    Cebra, J. (US)
    Tlaskalová, Helena (MBU-M) RID
    Source TitleInflammatory Bowel Disease. - Münster, 2005
    Pagess. 31-31
    Number of pages1 s.
    ActionInflammatory Bowel Disease
    Event date02.09.2005-03.09.2005
    VEvent locationMünster
    CountryDE - Germany
    Event typeWRD
    Languageeng - English
    CountryDE - Germany
    Keywordsprobiotic bacteria ; Escherichia coli
    Subject RIVEE - Microbiology, Virology
    R&D ProjectsGA303/04/0849 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z50200510 - MBU-M (2005-2011)
    AnnotationThe aim of our study was to evaluate the effect of Escherichia coli Nissle 1917 or Clostridium tyrobutyricum on the development of inflammatory bowel disease in conventional mice in dependence of the mucosal route of treatment. Experimental acute colitis was induced by administration of 2.5 % DSS in drinking water to immunodeficient SCID mice for seven days. One week prior to DSS exposure, the experimental groups of mice received daily either Escherichia coli Nissle 1917 or Clostridium tyrobutyricum by intragastrical tubing or intrarectaly. Intragastrical administration of bacteria had only mild effect on the intestinal inflammation, whereas mice treated per rectum remained healthy. We conclude that both applicated bacteria administrated per rectum impaired markedly the intestinal inflammation induced in mice by DSS administration and seems to be good candidates for enterocolitis prophylaxis
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2006
Number of the records: 1  

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