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Effect of probiotic bacteria and the routes of mucosal application on the severity
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SYSNO ASEP 0025570 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Effect of probiotic bacteria and the routes of mucosal application on the severity Title Vliv probiotických bakterií a způsob jejich podávání na experimentálně indukované intestinální záněty u myší Author(s) Hudcovic, Tomáš (MBU-M) RID, ORCID
Štěpánková, Renata (MBU-M) RID
Hrnčíř, Tomáš (MBU-M) RID, ORCID
Kozáková, Hana (MBU-M) RID, ORCID
Erban, V. (CZ)
Cebra, J. (US)
Tlaskalová, Helena (MBU-M) RIDSource Title Inflammatory Bowel Disease. - Münster, 2005 Pages s. 31-31 Number of pages 1 s. Action Inflammatory Bowel Disease Event date 02.09.2005-03.09.2005 VEvent location Münster Country DE - Germany Event type WRD Language eng - English Country DE - Germany Keywords probiotic bacteria ; Escherichia coli Subject RIV EE - Microbiology, Virology R&D Projects GA303/04/0849 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) Annotation The aim of our study was to evaluate the effect of Escherichia coli Nissle 1917 or Clostridium tyrobutyricum on the development of inflammatory bowel disease in conventional mice in dependence of the mucosal route of treatment. Experimental acute colitis was induced by administration of 2.5 % DSS in drinking water to immunodeficient SCID mice for seven days. One week prior to DSS exposure, the experimental groups of mice received daily either Escherichia coli Nissle 1917 or Clostridium tyrobutyricum by intragastrical tubing or intrarectaly. Intragastrical administration of bacteria had only mild effect on the intestinal inflammation, whereas mice treated per rectum remained healthy. We conclude that both applicated bacteria administrated per rectum impaired markedly the intestinal inflammation induced in mice by DSS administration and seems to be good candidates for enterocolitis prophylaxis Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2006
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