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Influence of intestinal non-cultivable bacteria on colitis developing in SCID mice
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SYSNO ASEP 0025559 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Influence of intestinal non-cultivable bacteria on colitis developing in SCID mice Title Vliv střevních nekultivovatelných bakterií na vývoj kolitidy u SCID myší po přenosu T buněk CD4+CD45RBhigh a strukturální změny tight junction (TJs) Author(s) Štěpánková, Renata (MBU-M) RID
Powrie, F. (GB)
Kofroňová, Olga (MBU-M) RID, ORCID
Kozáková, Hana (MBU-M) RID, ORCID
Hudcovic, Tomáš (MBU-M) RID, ORCID
Hrnčíř, Tomáš (MBU-M) RID, ORCID
Tlaskalová, Helena (MBU-M) RIDSource Title Inflammatory Bowel Disease. - Münster, 2005 Pages s. 26-26 Number of pages 1 s. Action Inflammatory Bowel Disease Event date 02.09.2005-03.09.2005 VEvent location Münster Country DE - Germany Event type WRD Language eng - English Country DE - Germany Keywords CD45RBhigh ; t cells Subject RIV EE - Microbiology, Virology R&D Projects GA303/04/0849 GA ČR - Czech Science Foundation (CSF) GA303/05/2249 GA ČR - Czech Science Foundation (CSF) IAA5020205 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50200510 - MBU-M (2005-2011) Annotation Colitis was present after transfer CD4+CD45RBhigh T cells only in conventional SCID mice and mice colonized with defined cocktail microflora plus noncultivated SFB bacteria. Altered tight junctions (TJs) was detected by antibodies against ZO-1 and Claudin-1 proteins and was detected in colitic mice. Increased numbers of CD4+ T cells in lamina propria and higher expression of IL-18R on colonocytes were found in colitic mice Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2006
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